Results for 'Danny Gene Wells'

959 found
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  1.  64
    Agonistic democracy and constitutionalism in the age of populism.Danny Michelsen - 2022 - European Journal of Political Theory 21 (1).
    The article examines the compatibility of agonistic democracy and populism as well as their relationship to the idea of constitutionalism. The first part shows that Chantal Mouffe’s recent attempts to reconcile her normative approach of an agonistic pluralism with a populist style of politics are not fully convincing. Although there are undeniable commonalities between an agonistic and a populist understanding of politics – the appreciation of conflict, the rejection of moralistic and juridical modes of conflict resolution etc. – the populist (...)
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  2.  51
    Are Socially Responsible Firms Associated with Socially Responsible Citizens? A Study of Social Distancing During the Covid-19 Pandemic.Danny Miller, Zhenyang Tang, Xiaowei Xu & Isabelle Le Breton-Miller - 2021 - Journal of Business Ethics 179 (2):387-410.
    The literature on the interplay between geographic communities and organizations has largely ignored the role of individual residents. In adopting a meso-perspective, we examine a potentially vital relationship between corporate conduct and pro-social behavior demanding sacrifice from individuals. Drawing on Weber ), we theorize that organizations in a community legitimize personal social conduct in three ways—by serving as role models, imparting norms and values, and routinizing forms of interaction. We study the relationship between corporate social responsibility behavior by local firms (...)
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  3.  53
    Condition a and scope reconstruction.Danny Fox - unknown
    It is well known that in certain environments the scope of a moved quantifier phrase can be determined at either its pre-movement position (“scope reconstruction”) or its postmovement position (“surface scope”). Thus the familiar ambiguity of (1) results from two choices for the scope of the moved QP. Under scope reconstruction, the scope of the moved existential QP is the sister of the pre-movement position (i.e. the sister of t, [to win the lottery]), while under surface scope it is the (...)
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  4. Haecceities: Logic, Metaphysics, Epistemics.Danny Frederick - manuscript
    I explain what haecceities are and the role they play in our thought and talk about specific individual things, whether those things are concrete or abstract. Everything that can be referred to by using a singular term has a haecceity. I distinguish between singular terms and general terms, on the one hand, and subject terms and predicate terms, on the other. I distinguish three types of sentence: singular predications; general predications; and singular quantifications. I show how singular predications can be (...)
     
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  5.  15
    Evaluating Spiritual Leadership Coherence at a Professional Services Company as a Way to Drive Connectedness and Well-Being in Organizations.Danny Sandra - 2022 - Humanistic Management Journal 7 (3):441-468.
    In these challenging times, connectedness has become more necessary than ever before. Meanwhile, research in organizations highlighted the importance of entrainment, a process of synchronizing rhythms over time that drives connectedness within, between, and across rhythmic activities. It is also suggested that an inner life and spiritual leadership coherence can play a key role in this process, out of which spiritual well-being emerges. The purpose of this study is to evaluate the conditions for entrainment through the revised model of spiritual (...)
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  6. Free choice and the theory of scalar implicatures* MIT,.Danny Fox - manuscript
    This paper will be concerned with the conjunctive interpretation of a family of disjunctive constructions. The relevant conjunctive interpretation, sometimes referred to as a “free choice effect,” (FC) is attested when a disjunctive sentence is embedded under an existential modal operator. I will provide evidence that the relevant generalization extends (with some caveats) to all constructions in which a disjunctive sentence appears under the scope of an existential quantifier, as well as to seemingly unrelated constructions in which conjunction appears under (...)
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  7. Sanction and obligation in Hart's theory of law.Danny Priel - 2008 - Ratio Juris 21 (3):404-411.
    Abstract. The paper begins by challenging Hart's argument aimed to show that sanctions are not part of the concept of law. It shows that in the "minimal" legal system as understood by Hart, sanctions may be required for keeping the legal system efficacious. I then draw a methodological conclusion from this argument, which challenges the view of Hart (and his followers) that legal philosophy should aim at discovering some general, politically neutral, conceptual truths about law. Instead, the aim should be (...)
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  8.  52
    The Good Bishop and the Explanation of Political Authority.Danny Frederick - 2016 - De Ethica 3 (2):23-35.
    A central problem of political philosophy is that of explaining how a state could have the moral authority to enforce laws, promulgate laws which citizens are thereby obliged to obey, give new duties to citizens and levy taxes. Many rival solutions to this problem of political authority have been offered by contemporary and recent philosophers but none has obtained wide acceptance. The current debate takes no cognisance of George Berkeley’s ‘Passive Obedience’, in which he defends the exceptionless duty of not (...)
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  9.  63
    Focus, parallelism and accommodation.Danny Fox - unknown
    It is well-known that constructions involving ellipsis share many properties with constructions that involve phonological reduction. The similarity between ECs and PRCs is semantic: the interpretation of both is constrained by the interpretation of an antecedent. Rooth and Tancredi have pointed out that this similarity follows from an independently needed theory of focus.
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  10.  33
    Successive Cyclic Movement and Island Repair: The Difference Between Sluicing and VP.Danny Fox - unknown
    It is well known that in Sluicing constructions wh-dependencies can cross certain projections that are otherwise barriers to movement (Ross (1969), Chomsky (1972)). This fact would follow under the assumption that the relevant barriers are somehow deactivated when phonologically deleted ('island repair'). The problem, however, is that another form of phonological deletion (VP Ellipsis, VPE) seems to be impossible in certain contexts where Sluicing allows for island repair (Chung et al. (1995), Merchant (1999)).
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  11.  55
    Introduction.Kalle Grill & Danny Scoccia - 2015 - Social Theory and Practice 41 (4):577-578.
    Introduction: Preference, Choice and (Libertarian) Paternalism Kalle Grill & Danny Scoccia This special issue originated in a workshop organized by one of the editors, Kalle Grill, at Umeå University in March 2014, with funding from The Swedish Foundation for Humanities and Social Sciences. The theme of the workshop was Respecting Context-Dependent Preferences. Contributors to this issue who were also speakers at the Umeå workshop are Richard Arneson, Kalle Grill, Jason Hanna, Sven Ove Hansson, Robert Sugden, and Torbjörn Tännsjö. The (...)
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  12. Critique of Brian earp's writing tips for philosophers.Danny Frederick - 2021 - Think 20 (58):81-87.
    I criticize Brian Earp's ‘Some Writing Tips for Philosophy’. Earp's article is useful for someone who wishes to do well in analytic philosophy as currently practised but it also casts doubt on why such analytic philosophy would be of interest to someone who wants to learn something new. In addition to its good tips, Earp's article contains two bad tips which, if followed, will tend to produce a paper that says next to nothing. I list the two faulty tips, show (...)
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  13.  26
    Learning Through Serving.Danny Reed - 2011 - Narrative Inquiry in Bioethics 1 (3):145-147.
    In lieu of an abstract, here is a brief excerpt of the content:Learning Through ServingDanny ReedI am a male CNA currently registered in Wisconsin since 1991, having worked as such since 1980 when I left high school. I have worked with ten different employers and many precious people I remember very well.I remember virtually everyone I have cared for in my over 30 years of work and yet there is not one person, place or moment that characterizes them all except (...)
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  14.  54
    Stressful Life Events and Subjective Well-Being in Vocational School Female Adolescents: The Mediating Role of Depression and the Moderating Role of Perceived Social Support.Mingkun Ouyang, Danni Gui, Xiao Cai, Yulong Yin, Xiaoling Mao, Shaoxu Huang, Pan Zeng & Pengcheng Wang - 2021 - Frontiers in Psychology 11.
    Stressful life events and subjective well-being are negatively related, but there is little research in the current literature exploring the mediating and moderating mechanisms underlying this association, especially for female adolescents in vocational schools who are subjected to undesirable life events. In the present study, we examined the mediating role of depression in the association between stressful life events and female adolescents’ subjective well-being, as well as the moderating role of perceived social support in the direct and indirect relations involved. (...)
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  15.  79
    Cyclic linearization of syntactic structure.Danny Fox - manuscript
    This paper proposes an architecture for the mapping between syntax and phonology — in particular, that aspect of phonology that determines ordering. In Fox and Pesetsky (in prep.), we will argue that this architecture, when combined with a general theory of syntactic domains ("phases"), provides a new understanding of a variety of phenomena that have received diverse accounts in the literature. This shorter paper focuses on two processes, both drawn from Scandinavian: the familiar process of Object Shift and the less (...)
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  16. Free will and probability.Danny Frederick - 2013 - Canadian Journal of Philosophy 43 (1):60-77.
    The chance objection to incompatibilist accounts of free action maintains that undetermined actions are not under the agent's control. Some attempts to circumvent this objection locate chance in events posterior to the action. Indeterministic-causation theories locate chance in events prior to the action. However, neither type of response gives an account of free action which avoids the chance objection. Chance must be located at the act of will if actions are to be both undetermined and under the agent's control. This (...)
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  17.  61
    Freedom, Indeterminism, and Fallibilism.Danny Frederick - 2020 - Cham, Switzerland: Palgrave Macmillan.
    This book uses the concepts of freedom, indeterminism, and fallibilism to solve, in a unified way, problems of free will, knowledge, reasoning, rationality, personhood, ethics and politics. Presenting an overarching theory of human freedom, Frederick argues for an account of free will as the capacity for undetermined acts. Knowledge, rationality, and reasoning, both theoretical and practical, as well as personhood, morality and political authority, are all shown to be dependent at their roots on indeterminism and fallibility, and to be connected (...)
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  18.  7
    Comparative Just War Theory.Luís Cordeiro-Rodrigues & Danny Singh (eds.) - 2020 - New York: Rowman & Littlefield.
    Widespread cross-cultural and cross-ideological agreement on the justifiable limits of war has become an increasingly complex yet vital element of global peace and conflict policies. Luís Cordeiro-Rodrigues and Danny Singh bring together a truly international cohort of philosophers, ethicists, political scientists, criminologists, sociologists, and other scholars to address the morality of war from a comparative perspective. While conceptions of when to enter war (jus ad bellum) and how to fight war (jus in bello) have been well researched in Western (...)
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  19. Promoting patient autonomy: Looking back.Gene H. Stollerman - 1984 - Theoretical Medicine and Bioethics 5 (1).
    The pinnacle of the physician's clinical skills is his ability to develop the autonomy of his patients in the management of their health affairs. To do this requires the forging of a relationship in which patients' attitudes toward their health and illness are products of the doctor-patient relationship rather than unilateral behavior by either one. Modern medicine is beset with problems that make it difficult for physicians to develop and exercise the skills that lead to patient autonomy. An erosion of (...)
     
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  20.  82
    Reason, Feeling, and Happiness: Bridging an Ancient/Modern Divide in The Plague.Gene Fendt - 2019 - Philosophy and Literature 43 (2):350-368.
    Camus is defined by many as an absurdist philosopher of revolt. The Plague, however, shows him working rigorously through a well-known division between ancient and modern ethics concerning the relation of reason, feeling and happiness. For Aristotle, the virtues are stable dispositions including affective and intellectual elements. For Kant, one’s particular feelings are either that from which we must abstract to judge moral worth, or are a constant hindrance to proper moral activity. Further, Kant claims “habit belongs to the physical (...)
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  21.  10
    (1 other version)The ethical journalist: making responsible decisions in the digital age.Gene Foreman - 2015 - Malden, MA: Wiley-Blackwell.
    A new edition of this well-regarded, student-friendly text book for journalism ethics that addresses the challenges of digital-age journalism.
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  22. The Augustinianism of Albert Camus' The Plague.Gene Fendt - 2020 - Heythrop Journal 61 (3):471-482.
    Camus himself called The Plague his most anti-Christian text, and most theologically oriented readings of the text agree. This paper shows how the sermons of Fr. Paneloux—an Augustine scholar--as well as Dr. Rieux’s mother present an Augustinian picture of love. This love opposes the passionate concupiscence for possession of things with the divine love which wishes for the constant conscious presence of the beloved in the light of the good. Such is possible for us, as Augustine exhibits and helps us (...)
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  23.  72
    The (Moral) Problem of Reading Confessions.Gene Fendt - 1998 - Proceedings of the American Catholic Philosophical Association 72:171-184.
    In Augustine's Confessions we can find two arguments against drama. One of them is entirely Platonic, echoing the problems raised in Republic 2 and 3 that representations of evil encourage moral turpitude. The other, which can be found in Republic 10, is much more visible in Confessions, and Augustine is more perspicuous than Plato in laying out the difficulty; it has to do with the immoral effect of suffering grief at staged sufferings, where we are moved neither to escape the (...)
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  24.  35
    Cross-Cultural Analysis of Volition: Action Orientation Is Associated With Less Anxious Motive Enactment and Greater Well-Being in Germany, New Zealand, and Bangladesh.Monischa B. Chatterjee, Nicola Baumann, Danny Osborne, Shamsul H. Mahmud & Sander L. Koole - 2018 - Frontiers in Psychology 9.
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  25.  30
    Environmental Education—Ponderings From Down Under.Gene C. Sager - 2001 - Global Bioethics 14 (1):105-111.
    This article describes and reflects upon Australia's extensive, federally-mandated, environmental education program. This program is based on a National Conservation Strategy which went into effect in 1989. But the program has massive support on the state and local levels as well. In addition to traditional classroom study of the environment and environmental issues, Audtralian Students do composting, re-vegetation of local canyons, and other hands-on activities. In many areas of the students' deatiledreports become the data base for the government's environmental monitoring (...)
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  26.  14
    The Relationship of Insufficient Effort Responding and Response Styles: An Online Experiment.Gene M. Alarcon & Michael A. Lee - 2022 - Frontiers in Psychology 12.
    While self-report data is a staple of modern psychological studies, they rely on participants accurately self-reporting. Two constructs that impede accurate results are insufficient effort responding and response styles. These constructs share conceptual underpinnings and both utilized to reduce cognitive effort when responding to self-report scales. Little research has extensively explored the relationship of the two constructs. The current study explored the relationship of the two constructs across even-point and odd-point scales, as well as before and after data cleaning procedures. (...)
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  27.  53
    The Use of Genetic Testing Information in the Insurance Industry: An Ethical and Societal Analysis of Public Policy Options.Paul Thistle, Gene Laczniak & Alexander Nill - 2019 - Journal of Business Ethics 156 (1):105-121.
    Informed by a search of the literature about the usage of genetic testing information (GTI) by insurance companies, this paper presents a practical ethical analysis of several distinct public policy options that might be used to govern or constrain GTI usage by insurance providers. As medical research advances and the extension to the Human Genome Project (2016, https://en.wikipedia.org/wiki/human_genome_project_-_write) moves to its fullness over the next decade, such research efforts will allow the full synthesis of human DNA to be connected to (...)
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  28.  6
    Quiet Quitting as Compensatory Respect: Meaningful Work, Recognition, and the Entrepreneurial Ethic.Thomas A. Corbin & Gene Flenady - 2024 - Philosophy of Management 23 (4):461-480.
    This paper employs Axel Honneth’s recognition theory to interpret ‘quiet quitting’ – the practice of limiting work efforts to contracted requirements – as a strategic response by workers facing misrecognition in their work environment. Honneth argues that misrecognition in any one of three social spheres (the family, political society, and the workplace) constitutes disrespect and causes psychological harm. While Honneth contends that experiences of disrespect tend to motivate collective “struggles for recognition,” we suggest that quiet quitters present an alternative response (...)
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  29.  62
    Children interpret disjunction as conjunction: Consequences for theories of implicature and child development.Raj Singh, Ken Wexler, Andrea Astle-Rahim, Deepthi Kamawar & Danny Fox - 2016 - Natural Language Semantics 24 (4):305-352.
    We present evidence that preschool children oftentimes understand disjunctive sentences as if they were conjunctive. The result holds for matrix disjunctions as well as disjunctions embedded under every. At the same time, there is evidence in the literature that children understand or as inclusive disjunction in downward-entailing contexts. We propose to explain this seemingly conflicting pattern of results by assuming that the child knows the inclusive disjunction semantics of or, and that the conjunctive inference is a scalar implicature. We make (...)
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  30.  83
    Liberty versus libertarianism.Gene Callahan - 2013 - Politics, Philosophy and Economics 12 (1):48-67.
    This paper aims to persuade its reader that libertarianism, at least in several of its varieties, is a species of the genus Michael Oakeshott referred to as ‘rationalism in politics’. I hope to demonstrate, employing the work of Oakeshott, as well as Aristotle and Onora O’Neill, how many libertarian theorists, who generally have a sincere and admirable commitment to personal liberty, have been led astray by the rationalist promise that we might be able to approach deductive certainty concerning the 'correctness' (...)
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  31.  19
    An ethics of anthropology‐informed community engagement with COVID‐19 clinical trials in Africa.Sarah J. L. Edwards, Blessing Silaigwana, Danny Asogun, Julius Mugwagwa, Francine Ntoumi, Rashid Ansumana, Kevin Bardosh & Jennyfer Ambe - 2023 - Developing World Bioethics 23 (3):242-251.
    The COVID‐19 pandemic has reinforced the critical role of ethics and community engagement in designing and conducting clinical research during infectious disease outbreaks where no vaccine or treatment already exists. In reviewing current practices across Africa, we distinguish between three distinct roles for community engagement in clinical research that are often conflated: 1) the importance of community engagement for identifying and honouring cultural sensitivities; 2) the importance of recognising the socio‐political context in which the research is proposed; and 3) the (...)
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  32. The Idea of a Social Cycle.Gene Callahan & Andreas Hoffman - manuscript
    The paper aims to explore what it means for something to be a social cycle, for a theory to be a social cycle theory, and to offer a suggestion for a simple, yet, we believe, fundamentally grounded schema for categorizing them. We show that a broad range of cycle theories can be described within the concept of disruption and adjustments. Further, many important cycle theories are true endogenous social cycle theories in which the theory provides a reason why the cycle (...)
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  33.  50
    The extended phenotype: a comparison with niche construction theory.David A. Wells - 2015 - Biology and Philosophy 30 (4):547-567.
    While niche construction theory locates animal artefacts in their constructors’ environment, hence treating them as capable of exerting selective pressure on both the constructors and their descendants, the extended phenotype concept assimilates artefacts with their constructors’ genes. Analogous contrasts apply in the case of endoparasite and brood parasite genes influencing host behaviour. The explanatory power of these competing approaches are assessed by re-examining the core chapters of Richard Dawkins’ _The Extended Phenotype_. Because animal artefacts have multiple evolutionary consequences for their (...)
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  34. Addiction: An Emergent Consequence of Elementary Choice Principles.Gene M. Heyman - 2013 - Inquiry: An Interdisciplinary Journal of Philosophy 56 (5):428 - 445.
    ABSTRACT Clinicians, researchers and the informed public have come to view addiction as a brain disease. However, in nature even extreme events often reflect normal processes, for instance the principles of plate tectonics explain earthquakes as well as the gradual changes in the face of the earth. In the same way, excessive drug use is predicted by general principles of choice. One of the implications of this result is that drugs do not turn addicts into compulsive drug users; they retain (...)
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  35. The Writ against Religious Drama: Frater Taciturnus v. Søren Kierkegaard.Gene Fendt - 1997 - In Niels Jørgen Cappelørn & Jon Bartley Stewart (eds.), Kierkegaard revisited: proceedings from the Conference "Kierkegaard and the Meaning of Meaning It", Copenhagen, May 5-9, 1996. New York: Walter de Gruyter. pp. 48-74.
    In a very literarily complicated setting, Frater Taciturnus sets a remark about Hamlet not being a Christian tragedy. After unpeeling that literary setting and noting that Taciturnus' remark aims more at Jacob Börne than at Shakespeare, the paper shows how Frater Taciturnus' remark calls into question the religious project of a certain danish author. For, Taciturnus' primary concern is to show that religious drama is not possible, or at least "ought not be." This general law applies to Hamlet as well, (...)
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  36. (1 other version)How to play the Platonic flute: Mimêsis and Truth in Republic X.Gene Fendt - 2018 - In How to play the Platonic flute: Mimêsis and Truth in Republic X. Sioux city, Iowa: pp. 37-48.
    The usual interpretation of Republic 10 takes it as Socrates’ multilevel philosophical demonstration of the untruth and dangerousness of mimesis and its required excision from a well ordered polity. Such readings miss the play of the Platonic mimesis which has within it precisely ordered antistrophes which turn its oft remarked strophes perfectly around. First, this argument, famously concluding to the unreliability of image-makers for producing knowledge begins with two images—the mirror (596e) and the painter. I will show both undercut the (...)
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  37. Physicality for Physicalists.D. Gene Witmer - 2018 - Topoi 37 (3):457-472.
    How should the “physical” in “physicalism” be understood? I here set out systematic criteria of adequacy, propose an account, and show how the account meets those criteria. The criteria of adequacy focus on the idea of rational management: to vindicate philosophical practice, the account must make it plausible that we can assess various questions about physicalism. The account on offer is dubbed the “Ideal Naturalist Physics” account, according to which the physical is that which appears in an ideal theory that (...)
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  38.  34
    Fibrillar collagen: The key to vertebrate evolution? A tale of molecular incest.Raymond P. Boot-Handford & Danny S. Tuckwell - 2003 - Bioessays 25 (2):142-151.
    Fibril‐forming (fibrillar) collagens are extracellular matrix proteins conserved in all multicellular animals. Vertebrate members of the fibrillar collagen family are essential for the formation of bone and teeth, tissues that characterise vertebrates. The potential role played by fibrillar collagens in vertebrate evolution has not been considered previously largely because the family has been around since the sponge and it was unclear precisely how and when those particular members now found in vertebrates first arose. We present evidence that the classical vertebrate (...)
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  39.  8
    A knight's code of business: how to achieve character and competence in the corporate world.Gene Del Vecchio - 2003 - Ithaca, N.Y.: Paramount Market. Edited by Roderick Fong.
    This clever and insightful book reveals the depth and breadth of high moral character and competence in the corporate world. The good news is that the corporate world, by and large, is in good shape. The bad news is that the bad apples number enough to make the rest of us vulnerable to their whims. A Knight?s Code of Business is the first book to arrive in the aftermath of high profiles disasters such as Enron and WorldCom. It presents both (...)
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  40.  61
    Aristotle on Dramatic Musical Composition. By Gregory Scott. [REVIEW]Gene Fendt - 2019 - Ancient Philosophy 39 (1):248-252.
    This is a review of Gregory Scott's book on Aristotle's Poetics, which he argues, with excellent and well-defended reasons, has the much narrow focus of dramatic musical art.
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  41.  85
    The “Integrative Justice Model” as Transformative Justice for Base-of-the-Pyramid Marketing.Tina M. Facca-Miess, Gene R. Laczniak & Nicholas J. C. Santos - 2015 - Journal of Business Ethics 126 (4):697-707.
    Writing in the Business and Politics, Santos and Laczniak 2012) formulated a normative, ethical approach to be followed when marketers e ngage impoverished market segments. It is labeled the integrative justice model. As noted below, that approach called for authentic engagement, co-creation, and customer interest representation, among other elements, when transacting with vulnerable market segments. Basically, the IJM derived certain operational virtues, implied by moral philosophy, to be used when marketing to the poor. But this well-intentioned approach raises a significant (...)
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  42.  22
    Patient portal access for caregivers of adult and geriatric patients: reframing the ethics of digital patient communication.Teja Ganta, Jacob M. Appel & Nicholas Genes - 2023 - Journal of Medical Ethics 49 (3):156-159.
    Patient portals are poised to transform health communication by empowering patients with rapid access to their own health data. The 21st Century Cures Act is a US federal law that, among other provisions, prevents health entities from engaging in practices that disrupt the exchange of electronic health information—a measure that may increase the usage of patient health portals. Caregiver access to patient portals, however, may lead to breaches in patient privacy and confidentiality if not managed properly through proxy accounts. We (...)
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  43.  21
    Higher levels of protective parenting are associated with better young adult health: exploration of mediation through epigenetic influences on pro-inflammatory processes.Steven R. H. Beach, Man Kit Lei, Gene H. Brody, Meeshanthini V. Dogan & Robert A. Philibert - 2015 - Frontiers in Psychology 6:138269.
    The current investigation was designed to examine the association of parenting during late childhood and early adolescence, a time of rapid physical development, with biological propensity for inflammation. Based on life course theory, it was hypothesized that parenting during this period of rapid growth and development would be associated with biological outcomes and self-reported health assessed in young adulthood. It was expected that association of parenting with health would be mediated either by effects on methylation of a key inflammatory factor, (...)
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  44. Genes in the postgenomic era.Paul E. Griffiths & Karola Stotz - 2006 - Theoretical Medicine and Bioethics 27 (6):499-521.
    We outline three very different concepts of the gene—instrumental, nominal, and postgenomic. The instrumental gene has a critical role in the construction and interpretation of experiments in which the relationship between genotype and phenotype is explored via hybridization between organisms or directly between nucleic acid molecules. It also plays an important theoretical role in the foundations of disciplines such as quantitative genetics and population genetics. The nominal gene is a critical practical tool, allowing stable communication between bioscientists (...)
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  45.  50
    A Gene-Free Formulation of Classical Quantitative Genetics Used to Examine Results and Interpretations Under Three Standard Assumptions.Peter J. Taylor - 2012 - Acta Biotheoretica 60 (4):357-378.
    Quantitative genetics (QG) analyses variation in traits of humans, other animals, or plants in ways that take account of the genealogical relatedness of the individuals whose traits are observed. “Classical” QG, where the analysis of variation does not involve data on measurable genetic or environmental entities or factors, is reformulated in this article using models that are free of hypothetical, idealized versions of such factors, while still allowing for defined degrees of relatedness among kinds of individuals or “varieties.” The (...) - free formulation encompasses situations encountered in human QG as well as in agricultural QG. This formulation is used to describe three standard assumptions involved in classical QG and provide plausible alternatives. Several concerns about the partitioning of trait variation into components and its interpretation, most of which have a long history of debate, are discussed in light of the gene-free formulation and alternative assumptions. That discussion is at a theoretical level, not dependent on empirical data in any particular situation. Additional lines of work to put the gene-free formulation and alternative assumptions into practice and to assess their empirical consequences are noted, but lie beyond the scope of this article. The three standard QG assumptions examined are: (1) partitioning of trait variation into components requires models of hypothetical, idealized genes with simple Mendelian inheritance and direct contributions to the trait; (2) all other things being equal, similarity in traits for relatives is proportional to the fraction shared by the relatives of all the genes that vary in the population (e.g., fraternal or dizygotic twins share half of the variable genes that identical or monozygotic twins share); (3) in analyses of human data, genotype-environment interaction variance (in the classical QG sense) can be discounted. The concerns about the partitioning of trait variation discussed include: the distinction between traits and underlying measurable factors; the possible heterogeneity in factors underlying the development of a trait; the kinds of data needed to estimate key empirical parameters; and interpretations based on contributions of hypothetical genes; as well as, in human studies, the labeling of residual variance as a non-shared environmental effect; and the importance of estimating interaction variance. (shrink)
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  46.  39
    Gene Doping—in Animals? Ethical Issues at the Intersection of Animal Use, Gene Editing, and Sports Ethics.Carolyn P. Neuhaus & Brendan Parent - 2019 - Cambridge Quarterly of Healthcare Ethics 28 (1):26-39.
    Abstract:Gene editors such as CRISPR could be used to create stronger, faster, or more resilient nonhuman animals. This is of keen interest to people who breed, train, race, and profit off the millions of animals used in sport that contribute billions of dollars to legal and illegal economies across the globe. People have tried for millennia to perfect sport animals; CRISPR proposes to do in one generation what might have taken decades previously. Moreover, gene editing may facilitate enhancing (...)
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  47.  37
    Gene × Environment Interaction in Developmental Disorders: Where Do We Stand and What’s Next?Gianluca Esposito, Atiqah Azhari & Jessica L. Borelli - 2018 - Frontiers in Psychology 9:394502.
    Although the field of psychiatry has witnessed the proliferation of studies on Gene x Environment (GxE) interactions, still limited is the knowledge we possess of GxE interactions regarding developmental disorders. In this perspective paper, we discuss why GxE interaction studies are needed to broaden our knowledge of developmental disorders. We also discuss the different roles of hazardous versus self-generated environmental factors and how these types of factors may differentially engage with an individual’s genetic background in predicting a resulting phenotype. (...)
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  48.  66
    Gene regulatory networks reused to build novel traits.Antónia Monteiro - 2012 - Bioessays 34 (3):181-186.
    Co‐option of the eye developmental gene regulatory network may have led to the appearance of novel functional traits on the wings of flies and butterflies. The first trait is a recently described wing organ in a species of extinct midge resembling the outer layers of the midge's own compound eye. The second trait is red pigment patches on Heliconius butterfly wings connected to the expression of an eye selector gene, optix. These examples, as well as others, are discussed (...)
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  49. What Genes Can't Do: Prolegomena to a Post Modern-Synthesis Philosophy.Lenny Moss - 1998 - Dissertation, Northwestern University
    The concept of the gene has been the central organizing theme of 20th century biology. Biology has become increasingly influential both for philosophers seeking a naturalized basis for epistemology, ethics, and the understanding of the mind, as well as for the human sciences generally. The central task of this work is to get the story right about genes and in so doing provide a critical and enabling resourse for use in the further pursuit of human self-understanding. ;The work begins (...)
     
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  50. Yesterday’s Child: How Gene Editing for Enhancement Will Produce Obsolescence—and Why It Matters.Robert Sparrow - 2019 - American Journal of Bioethics 19 (7):6-15.
    Despite the advent of CRISPR, safe and effective gene editing for human enhancement remains well beyond our current technological capabilities. For the discussion about enhancing human beings to be worth having, then, we must assume that gene-editing technology will improve rapidly. However, rapid progress in the development and application of any technology comes at a price: obsolescence. If the genetic enhancements we can provide children get better and better each year, then the enhancements granted to children born in (...)
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